September 15 2025 (Monday)
13:00 – 13:05
welcome
13:05 – 13:50
MasterclassCracking the Barrier: Vascular Biology and Brain Health
13:50 – 14:35
MasterclassCerebral Amyloid Angiopathy: An Update on Disease Mechanisms and Clinical Relevance for Stroke and Cognitive Impairment
SESSION 2: EMERGING TOOLS
14:55 – 15:40
MasterclassAI in VCID
15:40 – 16:25
MasterclassOPERATIONALIZING NEUROCOGNITIVE CONSTRUCTS: THE PROMISE OF NEW DIGITAL ASSESSMENT TECHNOLOGY
SESSION 3: CAREER DEVELOPMENT
16:45 – 18:00
Career Panel Planning a Career in Science
Conference day 1
September 16 2025 (Tuesday)
08:30 – 08:40
Opening ceremony – Welcome
Lord Mayor of Southampton, Cllr James Baillie, Roxane Carare (LOC), VasCog chair (Deb), Prashanti & Anna thanks
08:40 – 08:50
VasCog Award
THEME 1: NEW DIRECTIONS IN THE FIELD OF VASCULAR, BEHAVIORAL, AND COGNITIVE DISORDERS
Chairs: Anna Marseglia & Saima Hilal
08:50 – 09:05
Invited talkThe ARTS of Arteriolosclerosis
09:05 – 09:15
Invited talkMild Behavioral Impairment in VCI
09:15 – 09:30
Invited talkAdvancing VCI research with proteomics
09:30 – 09:40
oralSelected talk from abstract
09:40 – 09:50
oralSelected talk from abstract
09:50 – 10:00
oralSelected talk from abstract
10:05 – 10:20
clinical talkToo Much, Not Enough: Diagnosis in the Space Between
THEME 2A: BIOMARKERS OF VCI I – FLUID, RETINAL, CARDIAC
Chairs: Saima Hilal & Vera CAI Yuan
10:45 – 11:00
Invited talkBlood-based biomarkers in VCI
11:00 – 11:15
Invited talkRetinal vascular and neurodegenerative markers in VCI
11:15 – 11:30
Invited talkCardiac and Vascular Biomarkers of VCI”
11:30 – 11:40
oralSelected talk from abstract
11:40 – 11:50
oralSelected talk from abstract
11:50 – 12:00
oralSelected talk from abstract
13:30 – 14:20
Debate 1Is small vessel dysfunction the primary cause of dementia?
THEME 5: TREATMENT UPDATES
Chairs: Atticus Hainsworth & Russel Chander
14:25 – 14:40
Invited talkPDE5 inhibitors to treat small vessel disease in dementia
14:40 – 14:55
Invited talkTBD - preliminary talk - big proteomic data
14:55 – 15:10
Invited talkRemote ischemic conditioning in treating CSVD-related VCI
15:10 – 15:20
oralSelected talk from abstract
15:20 – 15:30
oralSelected talk from abstract
15:30 – 15:40
oralSelected talk from abstract
ECI sessionEarly Career Investigators Session - venue TBD
AWARD TALK FOR JOANNA WARDLAW
Chairs: Anna Williams & Atticus Hainsworth
16:30 – 16:35
welcome
16:30 – 16:40
Invited talkBrain Vascular Function and Small Vessel Disease: Evolving Insights from Imaging to Mechanisms
16:40 – 16:50
Invited talkFrom cellular biomarkers to clinical trajectories: Vascular dysfunction in small vessel disease progression
16:50 – 17:00
Invited talkSeeing the unseen: A legacy of discovery and vision
17:00 – 17:25
keynoteBrain Vascular Function and Small Vessel Disease: Evolving Insights from Imaging to Mechanisms
18:45
VASCOG DINNER AND PARTY
Location: Harbour Hotel, Southampton
Conference day 2
September 17 2025 (Wednesday)
Chairs: Annemieke ter Telgte & TBD
08:30 – 08:45
Invited talkTangled Pathologies – Exploring the Role of Arteriolosclerosis within Cerebral Amyloid Angiopathy
08:45 – 09:00
Invited talkPericyte–Endothelial Cell Miscommunication at the Blood–Brain Barrier: Insights into Dementia Pathophysiology
09:00 – 09:15
Invited talkPersistent Pathways: Inflammation and the Vicious Cycle of SVD
09:15 – 09:25
oralSelected talk from abstract
09:25 – 09:35
oralSelected talk from abstract
09:35 – 09:45
oralSelected talk from abstract
HOST TALK: CLEARANCE OF INTERSTITIAL FLUID (CLIC)
Chair: Roxana Carare
09:50 – 10:05
Invited talkTargeting Intramural Periarterial Drainage as a treatment in CAA
10:05 – 10:20
Invited talkCA-VB: a new mitochondrial target mediating cerebrovascular dysfunction and clearance in CAA and AD.
10:20 – 10:35
Invited talkTITLE TBD
10:35 – 10:50
Invited talkIntrathecal gene therapy in neurodegenerative diseases
Chairs: Audrey Low & Gurpreet Hansra
THEME 4: EPIDEMIOLOGY & RISK FACTORS FOR VCI
Chairs: Deborah Gustafson & Sarah-Naomi James
14:00 – 14:25
Invited talkVCI through a sex lens: cardiometabolic risk factors and small vessel disease
14:25 – 14:45
Invited talkTITLE TBD
14:45 – 15:00
Invited talkThe intersection between cardiovascular risk factors and non-communicable disease
15:00 – 15:10
oralSelected talk from abstract
15:10 – 15:20
oralSelected talk from abstract
15:20 – 15:30
oralSelected talk from abstract
15:30 – 17:30
MeetingAncillary meeting UK DRI-DPUK – Contact: Atticus Hainsworth/Joanna Wardlaw/Roxana Carare
Conference day 3
September 18 2025 (Thursday)
08:25
Information from CCCB team for the VasCog community
THEME 2B: BIOMARKERS OF VCI II – NEUROIMAGING
Chairs: Frank J Wolters & Julie Ottoy
08:30 – 08:45
Invited talkWhite matter hyperintensities in AD: beyond the vascular contribution to cognitive impairment
08:45 – 09:00
Invited talkSmall vessel disease and the structural shaping of the aging brain
09:00 – 09:15
Invited talkIntracranial arteriosclerosis: a major risk factor for VCI and dementia
09:15 – 09:25
oralSelected talk from abstract
09:25 – 09:35
oralSelected talk from abstract
09:35 – 09:45
oralSelected talk from abstract
09:50 – 10:40
panelLessons from lifestyle intervention trials
THEME 5: HEREDITARY SMALL VESSEL DISEASE AND VCI
11:05 – 11:20
Invited talkModeling disease progression in CADASIL: lessons for other cerebral SVD
11:20 – 11:35
Invited talkFrom early onset CADASIL to mild cognitive impairment in elderly: Understanding disease variability in NOTCH3-associated small vessel disease
11:35 – 11:50
Invited talkEast–West Differences and Similarities in CADASIL
11:50 – 12:00
oralSelected talk from abstract
12:00 – 12:10
oralSelected talk from abstract
12:10 – 12:20
oralSelected talk from abstract
12:25 – 13:00